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Trials in India to know right dose of aspirin


Ginny Narula,CNN-IBN
Feb 23, 2011 at 01:11pm IST

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New Delhi: Even after 100 years of use, doctors across the world have no clue how aspirin exactly works in protecting against heart attack and stroke.

India will now soon be part of a trial - conducted by Medanta Medicity in collaboration with Duke Medicine, North Carolina - to better understand aspirin's effect on the body.

"We're going to use newer modalities to study the effect of aspirin, how the body is responding in a fixed group of diseases," said Dr Sanjay Mittal, Director, Clinical Cardiology, Medanta Heart Institute.

Cardiologists prescribe aspirin from 81 milligrams to 325 milligrams a day hoping it will provide the best benefit to those at risk. Aspirin relieves pain and lowers the risk of heart attacks and strokes because it makes the blood clot less efficient. But aspirin is known to sometimes cause deadly stomach and intestinal bleeding.

"Aspirin has never been tested to say that what is the right dosage for various ailments to have the desired effect," said Dr Naresh Trehan, Cardiac Surgeon and Chairman of Medanta.

There is some evidence now that diabetics might need a higher dose of aspirin as high sugar levels could be making platelets resistant and thus clotting of blood.

Knowing the right dosage of aspirin for various ailments is the key to getting maximum health benefit for patients and the trials will be aiming just that.

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