Wayne Rooney sent Manchester United 15 points clear at the top of the Premier League on Saturday by scoring in a 1-0 victory over Reading.
Manchester City's fingertip hold on their Premier League title was loosened further after a demoralising 2-0 defeat at Everton on Saturday left them hoping for a footballing miracle.
Real Madrid trailed twice before fighting back with three goals in a seven-minute span to beat Mallorca 5-2 in the La Liga on Saturday and avoid another slip-up to a low-profile side.
Juventus marched on toward a 29th Serie A title by winning 2-0 at Bologna on Saturday to provisionally extend their lead to 12 points with Claudio Marchisio and Mirko Vucinic scoring.
Southampton took a big step toward avoiding relegation from the Premier League on Saturday by beating Liverpool 3-1 to provisionally move seven points clear of the drop zone.
Arsenal remained firmly in the race for Champions League qualification after Nacho Monreal and Gervinho secured a 2-0 win at Swansea on Saturday.