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Lionel Messi scored twice as Barcelona made the best start in the history of the Spanish league with a 5-1 win over Athletic Bilbao.
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Real Madrid extended their dominance over the second place Atletico Madrid by easing to a 2-0 victory in La Liga.
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Robin Van Persie scored the winning goal in the 34th minute as Manchester United defeated Reading 4-3.
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Swansea set a big upset as the two goals by Michu helped them defeat Arsenal 2-0 at Emirates Stadium.
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Marouane Fellaini put Everton in front at Manchester City but then conceded a penalty kick that allowed Carlos Tevez to clinch a 1-1 draw for City.
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Rafa Benitez's winless start as Chelsea manager worsened as West Ham took advantage of Chelsea's weak defense, and came from behind to beat their London rival 3-1.
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Liverpool recorded only its second win in seven Premier League matches by beating Southampton 1-0 from Daniel Agger's first-half goal.
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Juventus provisionally extended their Serie A lead by beating 10-man Torino 3-0 in the Turin derby.
AP