Juan Mata and Frank Lampard scored as Chelsea defeated Arsenal 2-1 at Stamford Bridge to stay solid at third place in the Premier League.
Clint Dempsey scored a dramatic equaliser in added time as Tottenham held Manchester United to a 1-1 draw at White Hart Lane.
Cristiano Ronaldo netted two goals and set up another to help Real Madrid thrash Valencia 5-0 in the La Liga.
Ten-man Barcelona lost their first match in the Spanish league on Saturday as Real Sociedad won the match 3-2 after trailing by two goals in the first half.
Luis Suarez and Daniel Sturridge scored as Liverpool thrashed Norwich City 5-0 in the EPL clash.
David Silva scored twice as Manchester City beat Fulham 2-0 on Saturday to keep the fight alive for the top spot with Manchester United.
Paul Pogba scored twice as Juventus thrashed Udinese 4-0 in Serie A clash.
Michael Owen scored his maiden goal for Stoke City, 150th in the Premier League and first in any competition in nearly 15 months.
Joe Cole's first goal in his second spell for West Ham denied Remy a dream debut for QPR following his club-record move from Marseille.
Robin Van Persie continued his good form against Tottenham as he scored one more time for United.