Van Persie scored 31 goals in his first season at Old Trafford, firing United to the Premier League title in 2013.
Bruce has not beaten his former club since becoming a manager and Hull have lost their last three league games.
Southampton are six points behind unbeaten Chelsea but two clear of City, seven ahead of United and already have 12 more than sputtering Liverpool.
Jonny Evans has played 60 minutes in a reserve match and could return to manager Louis van Gaal's injury-hit back line against Hull City.
United benefited from an own goal and then a late strike by Wayne Rooney to beat Arsenal to claim first away win of the season.
United manager Van Gaal will delve into the depths of his squad for the visit to Arsenal in the Premier League on Saturday, as an injury crisis engulfs Old Trafford.
Van Gaal says Daley Blind faces a "long" spell out after the midfielder hurt his left knee playing for the Netherlands in a European Championship qualifier.
United suffered a 10 per cent fall in first quarter revenue as the absence of lucrative Champions League soccer this season took its toll.
Daley Blind with a knee injury became the third United player to be crocked during the international break.
Manchester United midfielder Marouane Fellaini believes he was made the scapegoat for the team's torrid time under former manager David Moyes in the Premier League last season.
Moyes has agreed to take over as head coach of Real Sociedad until 30 June 2016, the La Liga club announced in a statement on Monday.